Difference between revisions of "HFE"
From Genetics Wiki
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| − | HFE is named after '''H'''igh '''Fe''' (iron). The protein has a signal sequence and transmembrane domain. | + | ''HFE'' is named after '''H'''igh '''Fe''' (iron). The gene products known function is to regulate iron absorption by interacting with transferrin and its receptor. |
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| + | =DNA Sequence= | ||
| + | ''HFE'' is located on chromosome 6 in humans. | ||
| + | |||
| + | =RNA Sequence= | ||
| + | There are several alternatively spliced variants of ''HFE''. | ||
| + | |||
| + | =Protein Sequence= | ||
| + | The protein has a signal sequence and transmembrane domain. It forms a tertiary complex with beta2-microglobulin (beta2M). ''HFE'' has sequence and structural similarity to MHC class I-type proteins. | ||
NCBI Protein[http://www.ncbi.nlm.nih.gov/protein/NP_000401] | NCBI Protein[http://www.ncbi.nlm.nih.gov/protein/NP_000401] | ||
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KVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRY | KVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRY | ||
TCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE</pre> | TCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE</pre> | ||
| − | |||
NCBI Structure[http://www.ncbi.nlm.nih.gov/structure?Db=structure&DbFrom=protein&Cmd=Link&LinkName=protein_structure&LinkReadableName=Structure&IdsFromResult=4504377] | NCBI Structure[http://www.ncbi.nlm.nih.gov/structure?Db=structure&DbFrom=protein&Cmd=Link&LinkName=protein_structure&LinkReadableName=Structure&IdsFromResult=4504377] | ||
Revision as of 09:23, 18 July 2014
HFE is named after High Fe (iron). The gene products known function is to regulate iron absorption by interacting with transferrin and its receptor.
DNA Sequence
HFE is located on chromosome 6 in humans.
RNA Sequence
There are several alternatively spliced variants of HFE.
Protein Sequence
The protein has a signal sequence and transmembrane domain. It forms a tertiary complex with beta2-microglobulin (beta2M). HFE has sequence and structural similarity to MHC class I-type proteins.
NCBI Protein[1]
>gi|4504377|ref|NP_000401.1| hereditary hemochromatosis protein isoform 1 precursor [Homo sapiens] MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEP RTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGY DGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLV KVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRY TCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
NCBI Structure[2]
UniProt protein accession: Q30201
Plot in Protter[3]
