Difference between revisions of "Gene Drive"

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*[[Meredith et al. 2013]]
 
*[[Meredith et al. 2013]]
 
*[[Eggleston 1991]]
 
*[[Eggleston 1991]]
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==Potential Application==
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More practical aspects of implementing threshold gene drive and population suppression.
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*In remote places in Hawaiʻi like the Alakaʻi drones might be useful to deliver modified mosquitoes over a large area. See https://www.nbcnews.com/mach/science/how-bug-delivering-drones-are-helping-defeat-deadly-diseases-ncna826691 perhaps combined with packing mosquitoes for delivery https://phys.org/news/2018-11-mail-mosquitoes-nice-snug.html
  
 
=Notes=
 
=Notes=

Latest revision as of 03:17, 11 November 2018

I am working towards organizing publications about gene drive topics here---this is not a complete listing. There is a lot of overlap with the topics of Sterile Insect Technique to suppress population numbers.

Misconceptions

Gene drive, to genetically engineer a population, and population suppression techniques, such as sterile insect technique, are often confused in the general media as being equivalent to each other. There is overlap in the methods and technologies used to achieve each, and they are not mutually exclusive, but they are two different concepts.

The recent focus on CRISPR/Cas9 has also caused a misconception of the equivalency between gene drive and CRISPR/Cas9. There are many more forms of gene drive than simply using a CRISPR/Cas9 mechanism and CRISPR/Cas9 drive is very similar to homing endonuclease drive.

There is also a misconception that this is a very new technology that only appeared in the last few years. However, work on gene drive goes back several decades to at least Curtis 1968 and is even proposed by Sandler and Novitski 1957. Many people are also surprised to learn that releases of mosquitoes, with modified chromosomes capable of both gene drive and population suppression, were carried out in field experiments in France in the 1970s (Laven et al. 1972). Some forms of these concepts even go back to the 1940s (Serebrovskii 1940; Vanderplank 1944).

Reviews

Drive Systems

Underdominance

Underdominance as an Effector Drive Mechanism

Underdominance as a Population Suppression Mechanism

Medea Systems

Inverse Medea

Naturally Occurring Medea

CRISPR/Cas9 Mechanism

Review

Drive

Population Suppression

Transposable Element Mechanism

Homing Endonuclease

Gene Drive

Population Suppression

Naturally Occurring

Meiotic Drive

Naturally Ocurring

Wolbachia

Population Suppression

Effector Drive

Killer-Rescue

News & Commentary

Public Interactions

Recommendations

See Also

Candidate Effector Genes

Notes

Shortening lifespan has a dramatic non-liner effect on reducing mosquito vectorial capacity (because mosquitoes have to live long enough to become infected from one bite and then later infect with another bite, McMeniman et al. 2009). There is a trade-off between fat metabolism, reproductive rate, and life-span in a range of organisms (e.g., Hansen et al. 2013). Effector genes that modulate lipid metabolism may result in reduced transmission of a wide range of mosquito vectored diseases.

Transgenesis Tools

Potential Application

More practical aspects of implementing threshold gene drive and population suppression.

Notes

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007039

https://fnih.org/what-we-do/current-lectures-awards-and-events/gene-drive-research-forum

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