Boyle et al. 2017

Citation

Boyle, E. A., Li, Y. I., & Pritchard, J. K. (2017). An expanded view of complex traits: from polygenic to omnigenic. Cell, 169(7), 1177-1186.

Links

• https://www.sciencedirect.com/science/article/pii/S0092867417306293
• http://hawaiireedlab.com/pdf/b/boyleetal2017.pdf (internal lab link only)

Notes

This is very well written and starts off by placing it in the broad historical overview of understanding the relationship between genotypes and phenotypes. This emphasizes that the results from GWAS suggest that pleiotropy and genetic heterogeneity are widespread and play a very important role in connecting genotype to phenotype (versus classical views like strict Mendalism, Garrod's one gene one function, and the philosophy of genetic dissection, yet these have been very successful approaches).

Simply searching for GO enrichment categories in GWAS may be a fundamental mistake.

This brings to mind a number of questions of the importance for the evolution of traits within and between species, and the authors spend some time discussing this.

...to be continued.