Difference between revisions of "Hardy 1908"
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| − | The tone of the first paragraph is a bit amusing, at least to a modern reader. It is hard to know how much of this is overt criticism versus formal language in 1908. However, this sentence is unambiguous, "I should have expected the very simple point which I wish to make to have been familiar to biologists". Hardy definitely felt that the question of expected genotype proportions was far too trivial for him to waste time upon yet was forced to do so by the misunderstandings of others. The irony is that this is probably the result for which he is best | + | The tone of the first paragraph is a bit amusing, at least to a modern reader. It is hard to know how much of this is overt criticism versus formal language in 1908. However, this sentence is unambiguous, "I should have expected the very simple point which I wish to make to have been familiar to biologists". Hardy definitely felt that the question of expected genotype proportions was far too trivial for him to waste time upon; yet, he was forced to do so by the blatant misunderstandings of others. The irony is that this is probably the result for which he is best known today. Elsewhere he keeps going with "a little mathematics of the multiplication-table type is enough to show ...", "it is easy to see ...", and "there is not the slightest foundation for the idea ...". |
At the time there was a debate about the general validity of Mendelian genetics in terms of understanding biological heritability. This was part of the Biometric-Mendelian Debate (or mutationalists versus selectionists), which was not resolved until the [[Modern Synthesis]] of biology later in the 20th century. One objection to Mendelian genetics that was brought up by Yule is that phenotypes in natural populations do not follow Mendelian proportions. The example of brachydactyly (shortened fingers and/or toes, one form of which is a dominant trait) in humans is used with the observation that the ratio of brachydactylus to unaffected individuals is not three to one. | At the time there was a debate about the general validity of Mendelian genetics in terms of understanding biological heritability. This was part of the Biometric-Mendelian Debate (or mutationalists versus selectionists), which was not resolved until the [[Modern Synthesis]] of biology later in the 20th century. One objection to Mendelian genetics that was brought up by Yule is that phenotypes in natural populations do not follow Mendelian proportions. The example of brachydactyly (shortened fingers and/or toes, one form of which is a dominant trait) in humans is used with the observation that the ratio of brachydactylus to unaffected individuals is not three to one. | ||
Revision as of 19:52, 1 September 2018
Citation
Hardy, G. H. (1908) Mendelian Proportions in a mixed population. Science 28(706): 49-50.
Links
https://www.jstor.org/stable/1636004
Notes
The tone of the first paragraph is a bit amusing, at least to a modern reader. It is hard to know how much of this is overt criticism versus formal language in 1908. However, this sentence is unambiguous, "I should have expected the very simple point which I wish to make to have been familiar to biologists". Hardy definitely felt that the question of expected genotype proportions was far too trivial for him to waste time upon; yet, he was forced to do so by the blatant misunderstandings of others. The irony is that this is probably the result for which he is best known today. Elsewhere he keeps going with "a little mathematics of the multiplication-table type is enough to show ...", "it is easy to see ...", and "there is not the slightest foundation for the idea ...".
At the time there was a debate about the general validity of Mendelian genetics in terms of understanding biological heritability. This was part of the Biometric-Mendelian Debate (or mutationalists versus selectionists), which was not resolved until the Modern Synthesis of biology later in the 20th century. One objection to Mendelian genetics that was brought up by Yule is that phenotypes in natural populations do not follow Mendelian proportions. The example of brachydactyly (shortened fingers and/or toes, one form of which is a dominant trait) in humans is used with the observation that the ratio of brachydactylus to unaffected individuals is not three to one.
| A | a | |
| A | AA | Aa |
| a | Aa | aa |
The Punnett Square above for an [math]F_2[/math] cross shows the expected offspring from two heterozygous parents with three brachydactylus offspring in red (genotypes AA and Aa) to one brachydactylus child in blue (aa).
