Difference between revisions of "Kimura 1968"
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Kimura constructs an estimate of the rate of genome-wide nucleotide substitutions based on observed amino acid differences between species. | Kimura constructs an estimate of the rate of genome-wide nucleotide substitutions based on observed amino acid differences between species. | ||
| − | *Average years between amino acid substitutions in 100 amino acids <math>=28\times10^6</math> a. | + | *Average years between amino acid substitutions in 100 amino acids <math>=28\times10^6</math> yr (today this would be "a", Latin ''annus'', symbolizing year). |
| − | *Genome size estimate <math>=4\times10^9</math> bp. | + | *Genome size estimate <math>=4\times10^9</math> bp (base pairs). |
*Gene size coreesponding to 100 amino acids <math>=300</math> bp. | *Gene size coreesponding to 100 amino acids <math>=300</math> bp. | ||
| − | *Adjustment to also include synonymous mutations that do not change the amino acid <math>1 + 0.2 = 1.2</math> | + | *Adjustment to also include an estimated additional 20% synonymous mutations that do not change the amino acid <math>1 + 0.2 = 1.2</math> |
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| + | <math>28\times10^6 \div \left( \frac{4\times10^9}{300} \right) \div 1.2 \doteqdot 1.8 {yr}</math> | ||
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| + | The publication (I don't know if this comes from Kimura or the typesetter) uses an obscure symbol, <math>\doteqdot</math>, for approximately equal to, <math>\approx</math>. | ||
[[Category:Publication]] | [[Category:Publication]] | ||
Revision as of 13:24, 15 September 2018
Contents
Citation
Kimura, M. (1968). Evolutionary rate at the molecular level. Nature, 217(5129), 624-626.
Links
- https://www.nature.com/articles/217624a0
- https://scholar.google.com/scholar?cluster=10145631598213248063
Notes
Paragraph Four
Kimura constructs an estimate of the rate of genome-wide nucleotide substitutions based on observed amino acid differences between species.
- Average years between amino acid substitutions in 100 amino acids [math]=28\times10^6[/math] yr (today this would be "a", Latin annus, symbolizing year).
- Genome size estimate [math]=4\times10^9[/math] bp (base pairs).
- Gene size coreesponding to 100 amino acids [math]=300[/math] bp.
- Adjustment to also include an estimated additional 20% synonymous mutations that do not change the amino acid [math]1 + 0.2 = 1.2[/math]
[math]28\times10^6 \div \left( \frac{4\times10^9}{300} \right) \div 1.2 \doteqdot 1.8 {yr}[/math]
The publication (I don't know if this comes from Kimura or the typesetter) uses an obscure symbol, [math]\doteqdot[/math], for approximately equal to, [math]\approx[/math].
