Reed and Tishkoff 2006a

Citation

Reed, F. A., & Tishkoff, S. A. (2006). Positive selection can create false hotspots of recombination. Genetics, 172(3), 2011-2014.

Links

• http://www.genetics.org/content/172/3/2011.short
• http://hawaiireedlab.com/pdf/r/reedandtishkoff2006a.pdf (internal lab link only)

Published Abstract

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.