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dedrick_et_al_2019 [2019/09/23 21:15]
floyd
dedrick_et_al_2019 [2019/09/23 21:17] (current)
floyd
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 ==Abstract== ==Abstract==
 A 15-year-old patient with cystic fibrosis with a disseminated //​Mycobacterium abscessus// infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious //M. abscessus// strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement,​ including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules. A 15-year-old patient with cystic fibrosis with a disseminated //​Mycobacterium abscessus// infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious //M. abscessus// strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement,​ including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
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 +{{tag>​Publication Phage Virus cystic_fibrosis Mycobacterium_abscessus phage_therapy}}
dedrick_et_al_2019.txt ยท Last modified: 2019/09/23 21:17 by floyd