haldane_1937
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haldane_1937 [2019/09/15 03:46] floyd |
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| - | Haldane, J. B. (1937). The effect of variation of fitness. //The American Naturalist//, | + | ====Haldane 1937==== |
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| + | Haldane, J. B. S. (1937). The effect of variation of fitness. //The American Naturalist//, | ||
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| Takeaway: Haldane considers the effects of deleterious mutations. Estimates are given for mutation-selection equilibrium allele frequencies and average reduction of fitness in the population. Fitness reduction is only a function of, and proportional to, mutation rates. The average individual in a population has a fitness that is a small fraction of the maximum theoretically possible if the genome were free of deleterious mutations. | Takeaway: Haldane considers the effects of deleterious mutations. Estimates are given for mutation-selection equilibrium allele frequencies and average reduction of fitness in the population. Fitness reduction is only a function of, and proportional to, mutation rates. The average individual in a population has a fitness that is a small fraction of the maximum theoretically possible if the genome were free of deleterious mutations. | ||
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| ===Notes=== | ===Notes=== | ||
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| - | Mutated copies are removed by selection each generation ($1-f$ survive). | + | Mutated copies are removed by selection each generation ($f$ survive). |
| $$N x (1-f) $$ | $$N x (1-f) $$ | ||
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| ==Multiple Loci== | ==Multiple Loci== | ||
| - | Assuming mutations are independent both in occurrence and in fitness effects the average individual in the population has an expected fitness of | + | Pages 345--346 describe the predictions over all loci in the genome. |
| $$F = \prod_i (1-m_i)$$ | $$F = \prod_i (1-m_i)$$ | ||
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| ==Other things== | ==Other things== | ||
| - | Haldane discusses the effects of inbreeding and sex-linkage on these prediction and goes through quite a bit of detail | + | Haldane discusses the effects of inbreeding and sex-linkage on these prediction and goes through quite a bit of additional logical details |
haldane_1937.txt · Last modified: 2019/09/16 03:35 by floyd
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