User Tools

Site Tools


haldane_1937

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
Next revision
Previous revision
haldane_1937 [2019/09/15 04:12]
floyd
haldane_1937 [2019/09/16 03:35] (current)
floyd
Line 1: Line 1:
 +====Haldane 1937====
 +
 Haldane, J. B. S. (1937). The effect of variation of fitness. //The American Naturalist//, 71(735), 337-349. Haldane, J. B. S. (1937). The effect of variation of fitness. //The American Naturalist//, 71(735), 337-349.
  
Line 8: Line 10:
  
 Takeaway: Haldane considers the effects of deleterious mutations. Estimates are given for mutation-selection equilibrium allele frequencies and average reduction of fitness in the population. Fitness reduction is only a function of, and proportional to, mutation rates. The average individual in a population has a fitness that is a small fraction of the maximum theoretically possible if the genome were free of deleterious mutations.  Takeaway: Haldane considers the effects of deleterious mutations. Estimates are given for mutation-selection equilibrium allele frequencies and average reduction of fitness in the population. Fitness reduction is only a function of, and proportional to, mutation rates. The average individual in a population has a fitness that is a small fraction of the maximum theoretically possible if the genome were free of deleterious mutations. 
 +
 +
  
 ===Notes=== ===Notes===
Line 99: Line 103:
 where $m$ is the mutation rate $\mu$ at the $i$<sup>th</sup> locus for recessive mutations and $m=2\mu$ for dominant effects.  where $m$ is the mutation rate $\mu$ at the $i$<sup>th</sup> locus for recessive mutations and $m=2\mu$ for dominant effects. 
  
-If the per nucleotide per generation mutation rate is $10^{-8}$ and a tenth of our 3.3 billion base pair genome is under purifying selection then+If the per nucleotide per generation mutation rate is $10^{-8}$a tenth of our 3.3 billion base pair genome is under purifying selection, and the majority of mutations are recessive in fitness effects then
  
-$$F \approx (1-10^{-8})^{3.3 \times 10^8}\approx 0.037 $$+$$F \approx (1-10^{-8})^{3.3 \times 10^8}\approx 0.037\mbox{.}$$
  
 Therefore, our fitness is predicted to be a small fraction, approximately 3--4%, of its theoretical maximum without mutations (both new mutations that have occurred in our own genomes and mutations that we have inherited from our ancestors).  Therefore, our fitness is predicted to be a small fraction, approximately 3--4%, of its theoretical maximum without mutations (both new mutations that have occurred in our own genomes and mutations that we have inherited from our ancestors). 
  
 ==Other things== ==Other things==
-Haldane discusses the effects of inbreeding and sex-linkage on these prediction and goes through quite a bit of detail in the introduction as well as some examples from insects. +Haldane discusses the effects of inbreeding and sex-linkage on these prediction and goes through quite a bit of additional logical details in the introduction as well as some examples from insects later in the paper
  
  
haldane_1937.1568520765.txt.gz ยท Last modified: 2019/09/15 04:12 by floyd