haldane_1937
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haldane_1937 [2019/09/15 04:43] floyd |
haldane_1937 [2019/09/16 03:35] (current) floyd |
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| where $m$ is the mutation rate $\mu$ at the $i$< | where $m$ is the mutation rate $\mu$ at the $i$< | ||
| - | If the per nucleotide per generation mutation rate is $10^{-8}$ | + | If the per nucleotide per generation mutation rate is $10^{-8}$, a tenth of our 3.3 billion base pair genome is under purifying selection, and the majority of mutations are recessive in fitness effects |
| - | $$F \approx (1-10^{-8})^{3.3 \times 10^8}\approx 0.037 $$ | + | $$F \approx (1-10^{-8})^{3.3 \times 10^8}\approx 0.037\mbox{.}$$ |
| Therefore, our fitness is predicted to be a small fraction, approximately 3--4%, of its theoretical maximum without mutations (both new mutations that have occurred in our own genomes and mutations that we have inherited from our ancestors). | Therefore, our fitness is predicted to be a small fraction, approximately 3--4%, of its theoretical maximum without mutations (both new mutations that have occurred in our own genomes and mutations that we have inherited from our ancestors). | ||
haldane_1937.1568522610.txt.gz ยท Last modified: 2019/09/15 04:43 by floyd
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