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haldane_1937 [2019/09/14 21:43]
floyd
haldane_1937 [2019/09/15 20:35] (current)
floyd
Line 103: Line 103:
 where $m$ is the mutation rate $\mu$ at the $i$<​sup>​th</​sup>​ locus for recessive mutations and $m=2\mu$ for dominant effects. ​ where $m$ is the mutation rate $\mu$ at the $i$<​sup>​th</​sup>​ locus for recessive mutations and $m=2\mu$ for dominant effects. ​
  
-If the per nucleotide per generation mutation rate is $10^{-8}$ ​and a tenth of our 3.3 billion base pair genome is under purifying selection then+If the per nucleotide per generation mutation rate is $10^{-8}$a tenth of our 3.3 billion base pair genome is under purifying selection, and the majority of mutations are recessive in fitness effects ​then
  
-$$F \approx (1-10^{-8})^{3.3 \times 10^8}\approx 0.037 $$+$$F \approx (1-10^{-8})^{3.3 \times 10^8}\approx 0.037\mbox{.}$$
  
 Therefore, our fitness is predicted to be a small fraction, approximately 3--4%, of its theoretical maximum without mutations (both new mutations that have occurred in our own genomes and mutations that we have inherited from our ancestors). ​ Therefore, our fitness is predicted to be a small fraction, approximately 3--4%, of its theoretical maximum without mutations (both new mutations that have occurred in our own genomes and mutations that we have inherited from our ancestors). ​
haldane_1937.txt ยท Last modified: 2019/09/15 20:35 by floyd