User Tools

Site Tools


publication:hanahan_and_weinberg_2011

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
publication:hanahan_and_weinberg_2011 [2019/09/14 15:01]
floyd
publication:hanahan_and_weinberg_2011 [2019/09/15 12:31] (current)
floyd
Line 1: Line 1:
 +===Hanahan and Weinberg 2011===
 +
 Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. //Cell//, 144(5), 646-674. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. //Cell//, 144(5), 646-674.
  
-Links+==Links==
   * https://​www.sciencedirect.com/​science/​article/​pii/​S0092867411001279   * https://​www.sciencedirect.com/​science/​article/​pii/​S0092867411001279
   * {{private:​hanahanandweinberg2011.pdf}} (internal lab link)   * {{private:​hanahanandweinberg2011.pdf}} (internal lab link)
  
-AbstractThe hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors,​ resisting cell death, enabling replicative immortality,​ inducing angiogenesis,​ and activating invasion and metastasis. Underlying these hallmarks are genome instability,​ which generates the genetic diversity that expedites their acquisition,​ and inflammation,​ which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. ​+==Abstract==  
 +The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors,​ resisting cell death, enabling replicative immortality,​ inducing angiogenesis,​ and activating invasion and metastasis. Underlying these hallmarks are genome instability,​ which generates the genetic diversity that expedites their acquisition,​ and inflammation,​ which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. ​
  
 {{tag>​Publication Cancer}} {{tag>​Publication Cancer}}
publication/hanahan_and_weinberg_2011.txt · Last modified: 2019/09/15 12:31 by floyd