allison_1956
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| ===Allison 1956=== | ===Allison 1956=== | ||
| - | Allison, A. C. (1956). The sickle‐cell and haemoglobin C genes in some African populations. Annals of Human Genetics, 21(1), 67-89. | + | Allison, A. C. (1956). The sickle‐cell and haemoglobin C genes in some African populations. |
| ==Links== | ==Links== | ||
| * https:// | * https:// | ||
| + | * {{private: | ||
| ==Summary== | ==Summary== | ||
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| 5. The high frequency of the haemoglobin C gene in the Gold Coast (about 6 %) is confirmed. Lower frequencies are recorded in Nigeria and Sierra Leone, and still lower frequencies in the Gambia. The gene appears to be very rare in, or absent from, the Southern Sudan, East Africa and the Belgian Congo. It is concluded that there is a single focus of the haemoglobin G gene in Africa, with a maximum frequency in or near the northern Gold Coast and a cline of descending frequencies on all sides. It is shown that there could be a stable polymorphism of the three alleles (HbA, Hbs and Hbc) in the Gold Coast under conditions of intensive selection where one heterozygote (HbsIHbc) is at a disadvantage and the other two heterozygotes are at an advantage. | 5. The high frequency of the haemoglobin C gene in the Gold Coast (about 6 %) is confirmed. Lower frequencies are recorded in Nigeria and Sierra Leone, and still lower frequencies in the Gambia. The gene appears to be very rare in, or absent from, the Southern Sudan, East Africa and the Belgian Congo. It is concluded that there is a single focus of the haemoglobin G gene in Africa, with a maximum frequency in or near the northern Gold Coast and a cline of descending frequencies on all sides. It is shown that there could be a stable polymorphism of the three alleles (HbA, Hbs and Hbc) in the Gold Coast under conditions of intensive selection where one heterozygote (HbsIHbc) is at a disadvantage and the other two heterozygotes are at an advantage. | ||
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allison_1956.1568574591.txt.gz · Last modified: 2019/09/15 19:09 by floyd
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