Negative Selection

http://www.pnas.org/content/94/16/8380

http://www.pnas.org/content/94/24/13034

http://www.genetics.org/content/202/3/869

https://www.sciencedirect.com/science/article/pii/S0168952500021880

https://www.biorxiv.org/content/early/2017/10/05/193482

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416010/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716299/

Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magnusson, G., ... & Wong, W. S. (2012). Rate of de novo mutations and the importance of father’s age to disease risk. Nature, 488(7412), 471.

http://hawaiireedlab.com/wpress/?p=2073