Vox posted an article, "The 7 biggest problems facing science, according to 270 scientists". I would have cast some of it differently and there are some alternative issues I might have focused on but it is worth reading over.  It closely mirrors a conversation I had with a grad student last week about struggling to deal with a feeling of cynicism and pessimism in science versus trying to stay positive and focused on research. The section headings are copied below to give you a feeling of what is discussed.

1. "Academia has a huge money problem"
2. "Too many studies are poorly designed"
3. "Replicating results is crucial — and rare"
4. "Peer review is broken"
5. "Too much science is locked behind paywalls"
6. "Science is poorly communicated"
7. "Life as a young academic is incredibly stressful"